Supplements: Natural or Synthetic?

By Lucy M. Stitzer August 27, 2024 | 6 MIN READ | UPDATED FROM MAY 2016

The Dirt

Can our body tell the difference between synthetic vs. natural vitamins? Are natural vitamins always better for us? Or do synthetic supplements have a place in our diets?

Nutrition

Supplements: Natural or Synthetic?

Diet

Food Regulations & Policy

Health and Nutrition

Ingredients

By Lucy M. Stitzer August 27, 2024 | 6 MIN READ | UPDATED FROM MAY 2016

The Dirt

Can our body tell the difference between synthetic vs. natural vitamins? Are natural vitamins always better for us? Or do synthetic supplements have a place in our diets?

There’s no doubt that vitamins and minerals are important to maintain both short- and long-term health. But does the source of the nutrients matter? You’ll find a lot of criticism about synthetic vitamins from various nutritionists and natural vitamin companies arguing that our bodies do not know how to digest these supplements.

But is this true? Or is this another marketing ploy to make you buy the more expensive, lesser processed vitamins?

What is a natural vitamin? 

Similar to ‘natural’ foods, the natural vitamin label is not clearly defined and can be very misleading. A natural vitamin can be made from a component directly from the earth or it can be ‘naturally made’ in your body through digestion. It can also be a product, like vitamin B, that begins with natural fermentation but is additionally processed.

synthetic vitamins, Supplements: Natural or Synthetic?All-natural vitamins are created directly from plant material. However, since supplements obviously don’t grow on trees, the only completely natural vitamin is something that comes directly from your food or made within our bodies.

To remove any vitamin from its natural source is a tricky and expensive process that also reduces the potency of the particular nutrient. So you have to ‘synthesize’ the vitamin anyway to reach full potency.

In our exploration of synthetic vitamins, we came across some great research from Willner Chemists, a nutritional pharmacy located in New York City. These pharmaceutical researchers explain the purpose of synthetic vitamins very clearly.

According to Dr. Donald Goldberg, R.Ph and Dr. Arnold Gitomer, R.Ph.:

“Yes, vitamins and minerals occur naturally in food. But the quantities are very small…

To get 500 milligrams of vitamin C and 10 milligrams of the various B vitamins from natural sources would require a tablet the size of a football.

With a few exceptions—such as vitamin E, natural beta-carotene, and vitamin B12—all of the vitamins used in dietary supplements are synthetic…these synthetic vitamins are identical to their natural counterparts. To get high potencies of vitamins and minerals in a dietary supplement, synthetic or highly processed vitamins, and minerals must be used. You cannot have it both ways.

What is a synthetic vitamin?

Synthetic nutrients are replicated in the lab to support their specific cellular structure and function. Because the vitamin is specifically isolated, the lab can easily control the purity and quality.

synthetic vitamins, Supplements: Natural or Synthetic?

The only exception is vitamin E, a crucial antioxidant. Vitamin C combined with vitamin E may increase the photoprotection of your skin more than vitamin E by itself.

Naturally-occurring vitamin E found in spinach, nuts, and oils, contains eight molecules called tocopherols and tocotrienols. A synthetic vitamin can only capture one tocopherol.

So here’s a helpful hint: Look for a ‘d’ label before the word alpha-tocopherol rather than a ‘dl’ label which means it is synthetic. This “dl” tip also works for determining the source for other vitamins, as well.

Aside from Vitamin E, there is no difference between natural and synthetic vitamins. In fact, 95% of vitamins on the market are synthetic, because it’s actually very difficult to put natural vitamins into most supplements.

Are natural vitamins healthier for our body?

“All-natural” vitamin companies often tout their process of creating “natural” vitamins as being better for your health. But one thing is true: natural supplements are typically far more taxing on your budget than synthetic supplements.

Natural vitamin companies often claim that your body will not know how to process vitamins that have been created synthetically. The main criticism is that synthetic vitamins are ‘isolated’ and since they are not working in conjunction with other vitamins, enzymes and minerals the human body does not recognize the isolated ones.

Contrary to this argument, reputable labs will actually create a ‘human stomach’ to test how the vitamins break down and release the nutrients. They copy the temperature, average acidity, and how the stomach churns during digestion. Of course, there are individual variants such as your gut microbiota, age, and overall health profile that will affect how your own body digests and absorbs the vitamin.

Are synthetic vitamins filled with unhealthy additives?

Companies producing all-natural vitamins indicate their products are free of artificial flavorings and colorings, chemical preservatives and other synthetic ingredients. Natural companies use only natural flavoring agents such as herbal extracts, lemon, and vanilla with no chemical dyes.

synthetic vitamins, Supplements: Natural or Synthetic?Synthetic supplements are criticized for using binders to hold tablets together, or fillers such as cellulose or magnesium stearate for encapsulation. However, not all of these processing ingredients are bad.

For instance, cellulose is a carbohydrate found in plants; if you eat lettuce or spinach, you are also eating cellulose.

Magnesium stearate is used to make sure the ingredients blend together proportionally and easily slides through the manufacturing process. It is basically a combination of stearic acid (a saturated fat found in beef, cocoa butter, and coconut oil) and magnesium salt. Both of these additives are generally regarded as safe by the FDA.

Regulation of vitamin products

The FDA and WHO do not distinguish between all natural and synthetic vitamins. In fact, dietary supplements are not regulated by the FDA the same way drugs are. This is due to the fact that you can make therapeutic claims for drugs, which you cannot do for dietary supplements.

In terms of vitamins, FDA regulations are responsible for the purity, potency, and safety of dietary supplements being created. They concur that the molecular structures of nutrients are well known and the body cannot tell if a nutrient came from a lab or a plant.

The question is not whether a vitamin is synthetic or natural, but was it made by a reputable manufacturer that uses FDA Good Manufacturing processes and uses a third-party company for their testing.

Be sure your vitamin supplements are tested for toxicity and contaminants, are properly labeled, and will break down in your body in the appropriate amount of time.

The Bottom Line

Natural vitamins cannot achieve the same potency as synthetic vitamins. When your diet falls short, a vitamin supplement is the best option to achieve the daily recommended amount. Not all vitamin supplements are created equal, so purchase natural Vitamin E supplements and check with your doctor to find a vitamin supplement that will work best for your body.